Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a unique gene encoding c-Kit to differentiate interneurons from other cell types. By using the c-kit mice in this study, the team was able to specifically access molecular layer interneurons and manipulate their activity using both optogenetic and chemogenetic methods in vitro.
Researchers have developed a technique for selectively targeting and controlling the interneurons of the cerebellar molecular layer relying on a genetically engineered mouse model that exploits a unique gene encoding c-Kit to differentiate interneurons from other cell types. By using the c-kit mice in this study, the team was able to specifically access molecular layer interneurons and manipulate their activity using both optogenetic and chemogenetic methods in vitro.
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